Striatal cell-type specific stability and reorganization underlying agency and habit.

ABSTRACT: Adaptive decision making requires agency, knowledge that actions produce particular outcomes. For well-practiced routines, agency is relinquished in favor of habit. Here, we asked how dorsomedial striatum D1⁺ and D2/A2A⁺ neurons contribute to agency and habit. We imaged calcium activity of these neurons as mice learned to lever press with agency and formed habits with overtraining. Whereas many D1⁺ neurons stably encoded actions throughout learning and developed encoding of reward outcomes, A2A⁺ neurons reorganized their encoding of actions from initial action-outcome learning to habit formation. Chemogenetic manipulations indicated that both D1⁺ and A2A⁺ neurons support action-outcome learning, but only D1⁺ neuro

SUBMITTER: Malvaez M 

PROVIDER: S-EPMC11785256 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature