Serum lipids mediate the association of per- and polyfluoroalkyl substances exposure and age-related macular degeneration.

ABSTRACT:

Background

This study aims to investigate the connection between serum lipids, per- and polyfluoroalkyl substances (PFAS), and age-related macular degeneration (AMD) risk and assess whether serum lipids mediate the association between PFAS and AMD.

Methods

1605 participants were enrolled from NHANES 2005-2008. Four serum PFAS levels with high detective rates, including perfluorononanoic acid (PFNA), perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorohexane sulfonic acid (PFHxS) were examined. Restricted cubic spline analysis (RCS) and weighted quantile sum (WQS) analysis were employed to detect nonlinear and mixed exposure effects.

Results

PFOS level was associated with any AMD (OR, 1.54; 95% CI, 1.12 to 2.11; P = 0.011), early AMD (OR,

SUBMITTER: Chen X 

PROVIDER: S-EPMC11785341 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature