A human pathogenic hantavirus circulates and is shed in taxonomically diverse rodent reservoirs.

ABSTRACT:

Background

Orthohantaviruses are negative-sense RNA viruses that can cause hantavirus cardiopulmonary syndrome (HCPS) in humans. In the United States, Sin Nombre orthohantavirus (SNV) is the primary cause of HCPS, with a fatality rate of 36% and most cases occuring in the southwestern states. The western deer mouse, Peromyscus sonoriensis, is the primary reservoir for SNV; however, it remains unclear if alternative reservoirs exist.

Results

We conducted an extensive survey of SNV genetic prevalence in wild-caught small mammal communities throughout New Mexico and observed that 27% of all animals were positive for SNV. Through longitudinal trapping at a site of patient exposure, we found that SNV circulates at a high rate in multiple species over time. Furthermore, we isolate

SUBMITTER: Goodfellow SM 

PROVIDER: S-EPMC11785344 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature