Atorvastatin versus placebo in patients with covid-19 in intensive care: randomized controlled trial.

ABSTRACT:

Objective

To assess the effect of statin treatment versus placebo on clinical outcomes in patients with covid-19 admitted to the intensive care unit (ICU).

Design

INSPIRATION/INSPIRATION-S was a multicenter, randomized controlled trial with a 2×2 factorial design. Results for the anticoagulation randomization have been reported previously. Results for the double blind randomization to atorvastatin versus placebo are reported here.

Setting

11 hospitals in Iran.

Participants

Adults aged ≥18 years with covid-19 admitted to the ICU.

Intervention

Atorvastatin 20 mg orally once daily versus placebo, to be continued for 30 days from randomization irrespective of hospital discharge status.

Main outcome measures

The primary efficacy outcome was a composite

SUBMITTER: INSPIRATION-S Investigators 

PROVIDER: S-EPMC11785411 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature