Incidence of Idiosyncratic Drug-Induced Liver Injury Caused by Prescription Drugs.

ABSTRACT:

Background

The incidence of drug-induced liver injury (DILI) is not known for most prescription medications. We aimed to estimate the incidence of DILI for commonly prescribed outpatient drugs.

Methods

To establish a baseline estimate of DILI incidence, we used the estimated incidence (EI) of amoxicillin/clavulanate DILI from a previous population-based study in Iceland. This was combined with the multicenter prospective DILI Network (DILIN) cohort and the US population-based Medical Expenditure Panel Survey (MEPS). From 2005 to 2019, prescription drugs with at least five bona fide DILIN cases and data from at least 10 of the 15 years from MEPS during that timeframe were included. The EI for 'drug A' was calculated as follows: EI(drug A)=EIAC×#DILIN cases of drug A#annual ne

SUBMITTER: Chen VL 

PROVIDER: S-EPMC11785493 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature