Metformin blocks BIK1-mediated CPK28 phosphorylation and enhances plant immunity.

ABSTRACT:

Introduction

Metformin (MET), derived from Galega officinalis, stands as the primary first-line medication for the treatment of type 2 diabetes (T2D). Despite its well-documented benefits in mammalian cellular processes, its functions and underlying mechanisms in plants remain unclear.

Objectives

This study aimed to elucidate MET's role in inducing plant immunity and investigate the associated mechanisms.

Methods

To investigate the impact of MET on enhancing plant immune responses, we conducted assays measuring defense gene expression, reactive oxygen species (ROS) accumulation, mitogen-activated protein kinase (MAPK) phosphorylation, and pathogen infection. Additionally, surface plasmon resonance (SPR) and microscale thermophoresis (MST) techniques were employed to i

SUBMITTER: Bao Y 

PROVIDER: S-EPMC11785555 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature