Melatonin alleviates high temperature exposure induced fetal growth restriction via the gut-placenta-fetus axis in pregnant mice.

ABSTRACT:

Introduction

Global warming augments the risk of adverse pregnancy outcomes in vulnerable expectant mothers. Pioneering investigations into heat stress (HS) have predominantly centered on its direct impact on reproductive functions, while the potential roles of gut microbiota, despite its significant influence on distant tissues, remain largely unexplored. Our understanding of deleterious mechanisms of HS and the development of effective intervention strategies to mitigate the detrimental impacts are still limited.

Objectives

In this study, we aimed to explore the mechanisms by which melatonin targets gut microbes to alleviate HS-induced reproductive impairment.

Methods

We firstly evaluated the alleviating effects of melatonin supplementation on HS-induced reproductiv

SUBMITTER: Wu JJ 

PROVIDER: S-EPMC11785557 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature