Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway.

ABSTRACT:

Introduction

Vascular calcification, a devastating vascular complication accompanying atherosclerotic cardiovascular disease and chronic kidney disease, increases the incidence of adverse cardiovascular events and compromises the efficacy of vascular interventions. However, effective therapeutic drugs and treatments to delay or prevent vascular calcification are lacking.

Objectives

This study was designed to test the therapeutic effects and mechanism of Moscatilin (also known as dendrophenol) from Dendrobium huoshanense (an eminent traditional Chinese medicine) in suppressing vascular calcification in vitro, ex vivo and in vivo.

Methods

Male C57BL/6J mice (25-week-old) were subjected to nicotine and vitamin D₃ (VD₃) treatment to induce vascular c

SUBMITTER: Zhang T 

PROVIDER: S-EPMC11785559 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature