Unlocking melanoma Suppression: Insights from Plasma-Induced potent miRNAs through PI3K-AKT-ZEB1 axis.

ABSTRACT:

Introduction

Melanoma is a rare but highly malignant form of skin cancer. Although recent targeted and immune-based therapies have improved survival rates by 10-15%, effective melanoma treatment remains challenging. Therefore, novel, combinatorial therapy options such as non-thermal atmospheric pressure plasma (NTP) are being investigated to inhibit and prevent chemoresistance. Although several studies have reported the apoptotic and inhibitory effects of reactive oxygen species produced by NTP in the context of melanoma, the intricate molecular network that determines the role of microRNAs (miRNAs) in regulating NTP-mediated cell death remains unexplored.

Objectives

This study aimed to explore the molecular mechanisms and miRNA networks regulated by NTP-induced oxidative st

SUBMITTER: Bhartiya P 

PROVIDER: S-EPMC11785563 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature