Collecting duct NCOR1 controls blood pressure by regulating mineralocorticoid receptor.

ABSTRACT:

Introduction

Nuclear receptor corepressor 1(NCOR1) is reported to play crucial roles in cardiovascular diseases, but its function in the kidney has remained obscure.

Objective

We aim to elucidate the role of collecting duct NCOR1 in blood pressure (BP) regulation.

Methods and results

Collecting duct NCOR1 knockout (KO) mice manifested increased BP and aggravated vascular and renal injury in an angiotensin II (Ang II)-induced hypertensive model. KO mice also showed significantly higher BP than littermate control (LC) mice in deoxycorticosterone acetate (DOCA)-salt model. Further study showed that collecting duct NCOR1 deficiency aggravated volume and sodium retention after saline challenge. Among the sodium transporter in the collecting duct, the expression of the thre

SUBMITTER: Sun K 

PROVIDER: S-EPMC11785564 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature