5-HT₇R enhances neuroimmune resilience and alleviates meningitis by promoting CCR5 ubiquitination.

ABSTRACT:

Introduction

Excessive immune activation induces tissue damage during infection. Compared to external strategies to reconstruct immune homeostasis, host balancing ways remain largely unclear.

Objectives

Here we found a neuroimmune way that prevents infection-induced tissue damage.

Methods

By FACS and histopathology analysis of brain Streptococcus pneumonia meningitis infection model and behavioral testing. Western blot, co-immunoprecipitation, and ubiquitination analyze the Fluoxetine initiate 5-HT7R-STUB1-CCR5 K48-linked ubiquitination degradation.

Results

Fluoxetine, a selective serotonin reuptake inhibitor, or the agonist of serotonin receptor 5-HT₇R, protects mice from meningitis by inhibiting CCR5-mediated excessive immune response and tissue da

SUBMITTER: Gao Z 

PROVIDER: S-EPMC11785565 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature