Baicalein induces apoptosis by inhibiting the glutamine-mTOR metabolic pathway in lung cancer.

ABSTRACT:

Introduction

Baicalein, a bioactive component of Scutellaria baicalensis Georgi, has been shown to promote apoptosis in non-small cell lung cancer cells. However, previous studies have not determined if baicalein exerts proapoptotic effects by modulating the metabolic pathways.

Objective

To investigate if baicalein induces apoptosis in lung cancer cells by modulating the glutamine-mTOR metabolic pathway.

Methods

The in vivo anti-lung cancer activity of baicalein (50, 100, and 200 mg/kg) was evaluated using a xenograft model. In vitro experiments were used to assess the efficacy of baicalein (for H1299: 12.5, 25, and 50 μM; for A549: 10, 20, and 40 μM) on lung cancer cell proliferation, colony formation, and apoptosis. Metabolomics analysis was performed using liquid c

SUBMITTER: Li J 

PROVIDER: S-EPMC11785570 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature