DNA hypomethylation-mediated upregulation of GADD45B facilitates airway inflammation and epithelial cell senescence in COPD.

ABSTRACT:

Introduction

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease typically characterized by chronic airway inflammation, with emerging evidence highlighting the driving role of cellular senescence-related lung aging. Accelerated lung aging and inflammation mutually reinforce each other, creating a detrimental cycle that contributes to disease progression. Growth arrest and DNA damage-inducible (GADD45) family has been reported to involve in multiple biological processes, including inflammation and senescence. However, the role of GADD45 family in COPD remains elusive.

Objectives

To investigate the role and mechanism of GADD45 family in COPD pathogenesis.

Methods

Expressions of GADD45 family were evaluated by bioinformatic analysis combined with det

SUBMITTER: Zhan Y 

PROVIDER: S-EPMC11785585 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature