Self-reported cancer-related cognitive impairment is associated with perturbed neurotransmission pathways.

ABSTRACT:

Background

Cancer-related cognitive impairment (CRCI) is reported by 45% of patients with cancer. Significant gaps in knowledge remain regarding the mechanisms that underlie CRCI.

Objectives

Using a data-driven approach, the study purpose was to evaluate for perturbed pathways associated with membership in the High versus the Low CRCI profiles.

Methods

Patients completed the Attentional Function Index six times over two cycles of chemotherapy. Using findings from a previous latent profile analysis, subgroups of patients with high versus low levels of CRCI were evaluated (i.e., High versus Low CRCI profiles). Gene expression was quantified using either ribonucleic (RNA)-sequencing or microarray analyses and pathway impact analyses were performed. Signaling pathways wer

SUBMITTER: Oppegaard KR 

PROVIDER: S-EPMC11785672 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature