A case of hyperviscosity syndrome associated with Waldenstrom macroglobulinemia treated with membrane plasma exchange without predilution.

ABSTRACT: A 75-year-old man with blurred vision and nasal bleeding was diagnosed with hyperviscosity syndrome and central retinal vein occlusion secondary to Waldenström macroglobulinemia. Serum total protein and IgM levels were undetectable. Because of the severe symptoms, we determined that immediate plasma-exchange treatment was required to decrease the blood viscosity. The initial plasma exchange was performed using the membrane isolation method with a predilution standby. A saline predilution replacement was prepared to decrease the total membrane pressure (TMP); however, the predilution protocol was not used because the planned treatment volume could be achieved without increasing the TMP. After two consecutive days of membrane plasma exchange, all serum biochemical tests were measurable, and

SUBMITTER: Saiki K 

PROVIDER: S-EPMC11785898 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature