Predicting accrual success for better clinical trial resource allocation.

ABSTRACT: Accrual success is one key determining factor for the success of clinical trials. Global data analyses of all terminated trials reported that 55% of trials were terminated due to low accrual rates. Failure to meet accrual goals have a significant impact on costs for sponsors, academic institutions, investigators, and society at large. The ability to predict trial accrual success with high precision before the trial starts would be highly valuable, preventing the allocation of critical resources for trials unlikely to meet accrual goals. In the present study, we constructed a dataset for predicting clinical trial failure based on poor accrual using clinicaltrial.gov data containing information on 57,846 trials. Features of the dataset were informed by prior literature and constructed using

SUBMITTER: Ma S 

PROVIDER: S-EPMC11785987 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature