"Shortening time to pregnancy in infertile women by personalizing treatment of microbial imbalance through Emma & Alice: A multicenter prospective study".

ABSTRACT:

Purpose

To evaluate the impact of Endometrial Microbiome Metagenomic Analysis and Analysis of Infectious Chronic Endometritis (EMMA & ALICE) on pregnancy outcomes following recommended treatments in women with recurrent implantation failure (RIF) or recurrent pregnancy loss (RPL).

Methods

This prospective, multicenter cohort study included 527 women under 42 years old with RIF or RPL across 14 IVF centers in Japan. Endometrial samples were analyzed using EMMA & ALICE, and patients received antibiotics, probiotics, or no treatment based on test results. Pregnancy outcomes were assessed using Kaplan-Meier survival analysis and multivariate generalized linear models.

Results

Amongst participants, 43.4% had a normal Lactobacillus-dominated microbiota, 20.9% had dysbiosis,

SUBMITTER: Iwami N 

PROVIDER: S-EPMC11786016 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature