HOXC-AS1 and EZH2 interaction increase HOXC9 expression and promote the malignant transformation of oral leukoplakia.

ABSTRACT: Objective: To investigate the role of HOXC9 in the transformation of oral leukoplakia (OLK) to oral squamous cell carcinoma (OSCC) and its effectiveness as a new molecular marker for oral leukoplakia carcinogenesis. Materials and Methods: We assessed HOXC9 in OLK and OSCC using immunohistochemistry (IHC). Colony formation and transwell experiment were employed to appraise the function of HOXC9 in the malignant transformation of OLK. ChIP-qPCR, CO-IP, RIP-qPCR, RNA pull down and mass spectrometry were using to evaluate the molecular mechanism of HOXC9. Results: HOXC9 expression was higher in patients with OSCC than in those with OLK, which is associated with increased malignant transformation of OLK. Functional experiments suggested that HOXC9 induces the acquisition of

SUBMITTER: Chen X 

PROVIDER: S-EPMC11786031 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature