AURKC Promotes Clear Cell Renal Cell Carcinoma Proliferation Through Upregulation of ERp57.

ABSTRACT: In recent years, aurora kinase C (AURKC) has emerged as a potential therapeutic target for cancer, having been found to induce proliferation in a variety of cancers. However, at present, its precise mechanism remains unclear. In this study, the specific role of AURKC in renal clear cell carcinoma and its mechanism was investigated. The protein expression levels of AURKC were evaluated in clear cell carcinoma and adjacent normal tissues, followed by prognostic analysis. Subsequently, cell models with knocked-down and overexpressed AURKC were constructed for in vitro cell experiments, and tumor-bearing mouse models were constructed to confirm the specific role of AURKC in vivo. AURKC was found to be highly expressed in ccRCC, which was associated with poor prognosis. In the

SUBMITTER: Liu Y 

PROVIDER: S-EPMC11786039 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature