Pan-Cancer Analysis of KANK2: Clinical and Molecular Insights into Tumor Progression and Therapeutic Implications.

ABSTRACT:

Background

KANK2, a gene crucial for cell migration and movement, is implicated in neoplastic and non-neoplastic diseases. This study aimed to analyze KANK2's expression and its diagnostic and prognostic significance across 33 cancers using multiple online databases.

Methods

This study aimed to comprehensively analyze KANK2 in 33 cancers using The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) database. Multiple web platforms and software were used for data analysis, including R, Cytoscape, HPA, TISIDB, UALCAN, GEO, cBioPortal, STRING, GSCALite, and CancerSEA. WB and qPCR experiments were used to verify the results.

Results

KANK2 is widely expressed in various tissues and has significant diagnostic value in multiple cancers, with AUC values exceeding

SUBMITTER: Zhao K 

PROVIDER: S-EPMC11786046 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature