Exploration of innovative drug repurposing strategies for combating human protozoan diseases: Advances, challenges, and opportunities.

ABSTRACT: Protozoan infections (e.g., malaria, trypanosomiasis, and toxoplasmosis) pose a considerable global burden on public health and socioeconomic problems, leading to high rates of morbidity and mortality. Due to the limited arsenal of effective drugs for these diseases, which are associated with devastating side effects and escalating drug resistance, there is an urgent need for innovative antiprotozoal drugs. The emergence of drug repurposing offers a low-cost approach to discovering new therapies for protozoan diseases. In this review, we summarize recent advances in drug repurposing for various human protozoan diseases and explore cost-effective strategies to identify viable new treatments. We highlight the cross-applicability of repurposed drugs across diverse diseases and harness common

SUBMITTER: Hu S 

PROVIDER: S-EPMC11786068 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature