Sex-specific differences in infective endocarditis: A systematic review and meta-analysis of clinical profiles and management outcomes.

ABSTRACT:

Background

Infective endocarditis (IE) presents significant morbidity and mortality, with potential sex differences in clinical profile and outcomes. This is the first meta-analysis that aims to compare the clinical profile and outcomes of IE between males and females.

Methods

We conducted a meta-analysis of nine studies evaluating the clinical profile and outcomes of IE in males versus females extracted from PubMed, EMBASE, SCOPUS, and Cochrane databases up to 1st of Jan 2024.

Results

Our meta-analysis revealed notable sex differences in the incidence and complications of IE. Males exhibited a higher incidence of aortic valve IE (RR 1.57, 95 % CI [1.31, 1.88]), surgical indications for IE (RR 1.38, [1.12, 1.70]), Streptococci infection (RR 1.36, [1.04, 1.77]), intrac

SUBMITTER: Salim HT 

PROVIDER: S-EPMC11786071 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature