Immune checkpoint inhibitor-related type 1 diabetes incidence, risk, and survival association.

ABSTRACT:

Aim/introduction

Although immune checkpoint inhibitor-related type 1 diabetes mellitus (ICI-T1DM) is a rare condition, it is of significant concern globally. We aimed to elucidate the precise incidence, risk factors, and impact of ICI-T1DM on survival outcomes.

Materials and methods

The study is a large retrospective cohort study, performed using the DeSC Japanese administrative claims database comprising 11 million patients. The database population is reportedly similar to the entire population of Japan. Patients administered ICI between 2014 and 2022 were enrolled in the study, including 21,121 patients. The risk factors for ICI-T1DM development and their characteristics were evaluated by logistic regression analysis. Development of a new irAE after the day following the f

SUBMITTER: Kamitani F 

PROVIDER: S-EPMC11786175 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature