Lipid signature changes of women with gestational diabetes mellitus in response to puerperal exclusive breastfeeding.

ABSTRACT:

Objective

We here investigated whether lactation during puerperium could help to reverse the diabetogenic effect of gestation and further explored the lipid profiling changes upon breastfeeding.

Methods

Thirty-five women diagnosed with GDM were recruited, and fasting plasma samples were collected at ~6 weeks postpartum. Maternal metabolic parameters were determined, and an untargeted lipidomic analysis was performed. The relationship between underlying lipidomic responses and lactation was explored.

Results

Improved glucose homeostasis and insulin sensitivity were observed in GDM women who adopted breastfeeding during the puerperium. Further lipidomics analysis revealed prominent correlations between lipid constitution changes and breastfeeding in women with GDM. A to

SUBMITTER: He J 

PROVIDER: S-EPMC11786177 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature