Blood metabolomic profile in patients with type 2 diabetes mellitus with diabetic peripheral neuropathic pain.

ABSTRACT:

Aims

This study aimed to identify metabolic markers for diabetic peripheral neuropathic pain (DPNP) in patients with type 2 diabetes mellitus (T2DM).

Materials and methods

Blood metabolite levels in the amino acid, biogenic amine, sphingomyelin, phosphatidylcholine (PC), carnitines, and hexose classes were analyzed in nondiabetic control (n = 27), T2DM without DPNP (n = 58), and T2DM with DPNP (n = 29) using liquid chromatography tandem mass spectrometry. Variable importance projection (VIP) evaluation by partial least squares discriminant analysis was performed on clinical parameters and metabolites.

Results

Sixteen variables with VIP > 1.0 (P < 0.05) were identified across all patient groups, and 5 variables were identified to discriminate between the two T2DM group

SUBMITTER: Kuo HC 

PROVIDER: S-EPMC11786186 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature