Glial activation among individuals with neurological post-acute sequelae of coronavirus disease 2019: A positron emission tomography study of brain fog using [¹⁸F]-FEPPA.

ABSTRACT:

Background

This study examined the regional distribution of glial activation in essential workers with neurological post-acute sequelae of coronavirus disease 2019 (COVID-19) infections (N-PASC).

Methods

We injected ≤185 MBq of [¹⁸F]-FEPPA as an intravenous bolus and positron-emission tomography over 2 h. To measure distribution volume (V_T) we recruited 24 essential workers (14 N-PASC, 10 Never-COVID-19 Controls, of whom 22 successfully placed arterial lines). Individuals with low binding affinity were excluded from this study, and V_T was adjusted for translocator protein genotype. Analyses that passed the false discovery rate are reported.

Results

Participants at midlife survived mild to moderate COVID-19 without hospitalization but r

SUBMITTER: Clouston SAP 

PROVIDER: S-EPMC11786203 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature