Deconditioning in quiescent Crohn's disease patients with heightened fatigue perception.

ABSTRACT:

Background and objective

Inflammatory bowel disease (IBD) fatigue aetiology is poorly understood. This study quantified body composition and physical function alongside proton magnetic resonance imaging (1H MRI) and spectroscopy (31P MRS) measures of organ structure and function in quiescent Crohn's disease patients (CD) and healthy volunteers (HVs), to identify a physiological basis for IBD fatigue.

Methods

Body composition was determined using dual-energy X-ray absorptiometry and 1H MRI. Knee extensor isometric strength and isokinetic fatigue were measured using dynamometry. 1H MRI was used to quantify cardiac output, cerebral blood flow (gmCBF), and brain oxygen extraction fraction (OEF) at rest, and during supine, steady-state exercise, and recovery. 31P MRS was used to

SUBMITTER: McGing JJ 

PROVIDER: S-EPMC11786219 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature