Cuproplasia-related gene signature: Prognostic insights for glioma therapy.

ABSTRACT:

Background

Adult-type diffuse gliomas encompass nearly a quarter of all primary tumors found in the CNS, including astrocytoma, oligodendroglioma, and glioblastoma. Histopathological tumor grade and molecular profile distinctly impact patient survival. Despite treatment advancements, patients with recurrent glioma have a very poor clinical outcome, warranting improved risk stratification to determine therapeutic interventions. Various studies have shown that copper is a notable trace element that is crucial for biological processes and has been shown to display pro-tumorigenic functions in cancer, particularly gliomas.

Methods

Differential gene expression, Cox regression, and least absolute shrinkage and selection operator regression were used to identify 19 copper-homeostas

SUBMITTER: Jue TR 

PROVIDER: S-EPMC11786221 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature