Survival Among Patients With ERBB2-Positive Metastatic Breast Cancer and Central Nervous System Disease.

ABSTRACT:

Importance

Approximately one-third of patients with ERBB2 (formerly HER2 or HER2/neu)-positive (ERBB2+) metastatic breast cancer (MBC) develop brain metastasis. It is unclear whether patients with disease limited to the central nervous system (CNS) have different outcomes and causes of death compared with those with concomitant extracranial metastasis.

Objective

To assess overall survival (OS) and CNS-related mortality among patients with ERBB2+ breast cancer and a diagnosis of CNS disease by disease distribution (CNS only vs CNS plus extracranial metastasis).

Design, setting, and participants

This single-center, retrospective cohort study included patients with ERBB2+ MBC and CNS disease, including parenchymal brain metastasis, leptomeningeal disease (LMD), or dural

SUBMITTER: Ferraro E 

PROVIDER: S-EPMC11786230 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature