Unraveling the causal role of sleep traits in development of diabetic retinopathy: A UK Biobank observational study and Mendelian randomization.

ABSTRACT:

Aims

To evaluate the potential causal role of sleep traits (STs) on diabetic retinopathy (DR).

Methods

The cross-sectional study included 23,851 patients with type 2 diabetes from the UK Biobank and used multivariate logistic models to investigate the observational association between STs and DR. Genetic correlation analysis and two-sample Mendelian randomization (MR) were conducted using ST data from the UK Biobank and DR data from the FinnGen consortium to investigate the genetic and causal associations between STs and DR.

Results

Patients who experienced daytime sleepiness often/all of the time had a higher risk for DR (OR: 1.40; 95% CI, 1.09-1.79; p = .008) compared with those who sometimes/never/rarely experienced daytime sleepiness. Genetic correlations b

SUBMITTER: Huang Y 

PROVIDER: S-EPMC11786281 | biostudies-literature | 2025 Jan-Feb

REPOSITORIES: biostudies-literature