Rewired chromatin structure and epigenetic gene dysregulation during HTLV-1 infection to leukemogenesis.

ABSTRACT: Human T-cell leukemia virus type 1 (HTLV-1) broadly impacts host genes, affecting the infected cell population and inducing the development of a disease with a poor prognosis, adult T-cell leukemia-lymphoma (ATL). This study aimed to provide a comprehensive epigenomic characterization of the infected cell population and evaluated the transcriptome and chromatin structures of peripheral blood cells in HTLV-1-infected individuals using RNA sequencing (RNA-seq) and assay for transposase-accessible chromatin sequencing (ATAC-seq). The infected cells showed significant changes in gene expression patterns from the polyclonal stage and before ATL onset while demonstrating similarities to tumor-forming ATL cells. These similarities were a result of large-scale open chromatin changes, supporting th

SUBMITTER: Mizuike J 

PROVIDER: S-EPMC11786301 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature