Pan-immune-inflammation value predicts immunotherapy response and reflects local antitumor immune response in rectal cancer.

ABSTRACT: The pan-immune-inflammation value reflects the systemic inflammatory response, and tumor-infiltrating lymphocytes indicate a local immune response in rectal cancer. However, the association between systemic inflammatory response, as indicated by the pan-immune-inflammation value, and local immune responses in rectal cancer remains unclear. This study analyzed 915 treatment-naïve rectal cancer patients from the Peking Union Medical College Hospital and PLA General Hospital (PLAGH) cohorts who underwent radical surgery to investigate the relationship between the pan-immune-inflammation value and immune responses. Lower pan-immune-inflammation value was significantly associated with improved disease-free survival and cancer-specific survival. Multivariate Cox regression models identified the

SUBMITTER: Wang Q 

PROVIDER: S-EPMC11786305 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature