Exploring the tumor microenvironment of colorectal cancer patients post renal transplantation by single-cell analysis.

ABSTRACT: Patients with colorectal cancer (CRC) following renal transplantation require long-term immunosuppressants to prevent graft rejection. However, the impact of these immunosuppressants on the tumor immune microenvironment and the roles of immune cells within it remain poorly understood. We conducted comprehensive single-cell RNA sequencing on tumor and normal tissues from four CRC patients post renal transplantation and compared these with published data from 23 non-transplant CRC patients. We set four groups for detailed comparative analysis based on the renal transplantation status and tissue origin: non-renal transplantation normal (nRT_Normal), non-renal transplantation tumor (nRT_Tumor), renal transplantation normal (RT_Normal), renal transplantation tumor (RT_Tumor). Our analysis revea

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11786312 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature