GPNMB is a novel binding partner of FGFR1 that affects tumorigenic potential through AKT phosphorylation in TNBC.

ABSTRACT: Breast cancer is a heterogeneous disease and is one of the most prevalent cancers in women. Triple-negative breast cancer (TNBC) is a relatively aggressive subtype of breast cancer, which is difficult to treat. Glycoprotein nonmetastatic melanoma protein B (GPNMB) is a type I transmembrane protein that is overexpressed in various types of cancers, including breast cancer, especially TNBC. In this study, bioinformatic analyses revealed enhanced fibroblast growth factor receptor 1 (FGFR1) signaling in patients with invasive breast cancer, and the GPNMB^high/FGFR1^high group exhibited a lower probability of relapse-free survival (RFS) than the GPNMB^low/FGFR1^low group. Additionally, we observed that GPNMB and FGFR1 were essential for sphere formation,

SUBMITTER: Elhinnawi MA 

PROVIDER: S-EPMC11786315 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature