Treatment of rheumatoid arthritis using dual-targeted and dual-response intelligent micelles: a "three birds with one stone" strategy.

ABSTRACT: Rheumatoid arthritis (RA) is an autoimmune disease whose pathophysiology is closely related to inflammation-associated cells and the microenvironment of inflamed joints. This study aimed to develop dual-targeted, reactive oxygen species (ROS)/pH dual-responsive, size-shrinkable intelligent micelles targeting M1 macrophages and fibroblast-like synoviocytes (FLSs) to enhance drug efficacy and safety. These micelles were surface-modified with PEG₅₀₀₀ to prolong their circulation time in the bloodstream and hide the targeting molecules. The optimized particle size allowed the micelles to reside in inflamed joints through the extravasation through leaky vasculature and subsequent inflammatory cell-mediated sequestration (ELVIS) effect. The high concentration of ROS in the inflamed jo

SUBMITTER: Guo RB 

PROVIDER: S-EPMC11786335 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature