The impact of chronic intermittent hypoxia on enzymatic activity in memory-associated brain regions of male and female rats.

ABSTRACT:

Background

Obstructive sleep apnea (OSA) is an intermittent hypoxia disorder associated with cognitive dysfunction, including learning and memory impairments. There is evidence that alterations in protease activity and neuronal activation are associated with cognitive dysfunction, are dependent on sex, and may be brain region-specific. However, the mechanisms mediating OSA-induced cognitive impairments are unclear. Therefore, we used a rat model of OSA, chronic intermittent hypoxia (CIH) to investigate protease activity (e.g., calpain and caspase-3) on spectrin, a cytoskeletal protein associated with neurotransmitter release, and neuronal activation (early growth response protein 1, EGR-1) in brain regions associated with learning and memory.

Methods

Male and female Sprague

SUBMITTER: Mabry S 

PROVIDER: S-EPMC11786371 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature