Mediating Mendelian randomization in the proteome identified potential drug targets for obesity-related allergic asthma.

ABSTRACT:

Background

With the development of the economy, the number of obese patients has been increasing annually worldwide. The proportion of asthma patients associated with obesity is also gradually rising. However, the pathogenesis of obesity-related asthma remains incompletely understood, and conventional pharmacological treatments generally show limited efficacy.

Objective

This study aims to explore the causal relationship between obesity and allergic asthma, elucidate the pathogenesis of obesity-related asthma, and identify the plasma proteins involved in its development, providing new insights for clinical interventions.

Methods

In this study, we employed a two-step approach for mediation Mendelian randomization (MR) analysis, utilizing stringent selection criteria to

SUBMITTER: Lin J 

PROVIDER: S-EPMC11786417 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature