Rotation errors in path integration are associated with Alzheimer's disease tau pathology: a cross-sectional study.

ABSTRACT:

Background

Early Alzheimer's disease diagnosis is crucial for preventive therapy development. Standard neuropsychological evaluation does not identify clinically normal individuals with brain amyloidosis, the first stage of the pathology, defined as preclinical Alzheimer's disease. Spatial navigation assessment, in particular path integration, appears promising to detect preclinical symptoms, as the medial temporal lobe plays a key role in navigation and is the first cortical region affected by tau pathology.

Methods

We have conducted a cross-sectional study. We related the path integration performance of 102 individuals without dementia, aged over 50, to amyloid and tau pathologies, measured using positron emission tomography. We included 75 clinically normal individuals (1

SUBMITTER: Colmant L 

PROVIDER: S-EPMC11786419 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature