Multi-omics dissection of metabolic dysregulation associated with immune recovery in people living with HIV-1.

ABSTRACT:

Background

Despite the success of antiretroviral therapy (ART) in suppressing HIV-1 replication, some people living with HIV-1 (PLWH) fail to achieve an optimal recovery of CD4 T cells, and precise metabolic regulation underlying immune recovery remained poorly understood.

Methods

In this cross-sectional study, mass spectrometry was used for quantitative analysis of plasma metabolome and lipidome in 24 treatment-naïve PLWH (TNs), 33 immunological responders (IRs), 35 immunological non-responders (INRs), and 16 healthy controls (HCs). The data were analyzed using the Mann-Whitney U-test, Kruskal-Wallis test, Spearman correlation, and LASSO regression analysis.

Results

Significant metabolic dysregulation was observed in TNs, IRs and INRs compared to HCs. In TNs, metabol

SUBMITTER: Wan LY 

PROVIDER: S-EPMC11786453 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature