How to improve the quality of euglycemic glucose clamp tests in long-acting insulin studies.

ABSTRACT:

Background

The euglycemic clamp test stands as the best method for assessing the pharmacokinetic and pharmacodynamic properties of long-acting insulin. However, despite its widespread use, there remains a notable absence of an established gold standard for evaluating the test's quality. Existing recommendations from regulatory agencies lack specific threshold values, particularly concerning long-acting insulin. This study aimed to determine the evaluation criteria for assessing the quality of the long-acting insulin euglycemic glucose clamp test and to improve the overall quality of this testing method.

Methods

Fifty-three healthy volunteers were administered a single dose of insulin degludec (0.4 IU/kg) and underwent a 24-h euglycemic clamp test. Blood samples were collecte

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11786465 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature