Retinal optical coherence tomography intensity spatial correlation features as new biomarkers for confirmed Alzheimer's disease.

ABSTRACT:

Background

The nature and severity of Alzheimer's disease (AD) pathologies in the retina and brain correspond. However, retinal biomarkers need to be validated in clinical cohorts with confirmed AD biomarkers and optical coherence tomography (OCT). The main objective of this study was to investigate whether retinal metrics measured by OCT aid in the early screening and brain pathology monitoring for confirmed AD.

Methods

This was a case-control study. All participants underwent retinal OCT imaging, and neurological examinations, including amyloid-β (Aβ) positron emission tomography. Participants were subdivided into cognitively normal (CN), mild cognitive impairment (MCI), and AD-derived dementia (ADD). Except retinal thickness, we developed the grey level co-occurrence matr

SUBMITTER: Jin Z 

PROVIDER: S-EPMC11786474 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature