Association between life's essential 8 and Parkinson's disease: a case-control study.

ABSTRACT:

Objectives

Life's essential 8 (LE8) is an emerging approach for accessing and quantifying cardiovascular health (CVH), but the effect on Parkinson's disease (PD) is still unclear. This study aimed to elucidate the association between LE8 metrics and PD in the US adults.

Methods

Data of 26,975 participants were extracted from the last 7 National Health and Nutrition Examination Survey (NHANES) cycles (2005-2018). The LE8 metrics were calculated according to the American Heart Association criterion, and participants were divided into 3 groups using tertile range. Multivariate logistic regression models were constructed to explore the association between LE8 metrics and PD. Sensitivity analysis was conducted to verify robustness. A nonlinear linkage was evaluated via restricted

SUBMITTER: Fan J 

PROVIDER: S-EPMC11786534 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature