Microvascular dysfunction causing myocardial ischemia in obstructive hypertrophic cardiomyopathy.

ABSTRACT: Hypertrophic cardiomyopathy (HCM) is characterized by myocardial hypertrophy and can lead to significant complications including left ventricular outflow tract obstruction (LVOTO) and myocardial ischemia. Microvascular dysfunction (MVD) is a less recognized but crucial cause of myocardial ischemia in HCM, contributing to myocardial injury in the absence of obstructive coronary artery disease. We presented a case of a 48-year-old male with retrosternal chest tightness radiating to the left arm for 3 h. Electrocardiography revealed left ventricular (LV) hypertrophy with ST-segment depression and T wave inversion. High-sensitivity troponin T levels were elevated. Echocardiography showed marked LV wall thickness, predominantly at the basal septum, with systolic anterior motion of anterior mitr

SUBMITTER: Theerasuwipakorn N 

PROVIDER: S-EPMC11786631 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature