Effects of housing conditions on health and gut microbiome of female cynomolgus monkeys and improvement of welfare by checking menstruation under socially housed condition.

ABSTRACT: Laboratory non-human primates (NHPs) are commonly subjected to social deprivation in various scientific researches. However, the impact of social deprivation on gut microbiome remains largely unknown. We examined the health status and gut microbiota of female cynomolgus monkeys housed in isolation or social conditions and found that social deprivation brought adverse effects to monkeys by inhibiting their growth, remodeling the immune status, and decreasing the level of beneficial biochemical parameters. 16S rRNA gene sequencing revealed that the gut microbial composition and function differed between grouped and isolated monkeys. Specifically, grouping the single-caged young monkeys to socially housed condition could decrease the relative abundance of Firmicutes and increase the relative

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11786677 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature