Hematopoietic stem cell discovery: unveiling the historical and future perspective of colony-forming units assay.

ABSTRACT: Stem cells are special cells with the distinctive capability to self-renew, forming a new pool of undifferentiated stem cells. They are also able to differentiate into lineage-specific cell types that are specialized and matured. Thus, stem cells are considered as the building blocks of tissues and organs in which they reside. Among the many types of stem cells, hematopoietic stem cells (HSCs) are the most studied adult stem cells and are considered as a promising source of cells for applications in the clinical and basic sciences. Historically, research on HSCs was initiated in the 1940s, where in a groundbreaking experiment, intravenously injected bone marrow (BM) cells prevented the death of irradiated mice by restoring blood cell production. Since then, HSCs have been studied and utili

SUBMITTER: Yusoff NA 

PROVIDER: S-EPMC11786707 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature