Potentialities and critical issues of liquid biopsy in clinical practice: An umbrella review.

ABSTRACT:

Background

Liquid biopsy (LB) is a laboratory test performed on a fluid sample aiming at analyzing molecular data derived from circulating cells and related entities, or from nucleic acids. This umbrella review aims to map and evaluate the evidence supporting the use of LB in medicine across different medical specialities and conditions.

Methods

We searched three repositories from database inception up to October 1, 2023 and we included meta-analyses of observational studies reporting data on the use of LB, compared to gold standard, and its accuracy (area under the curve, AUC).

Results

Among 726 articles initially screened, 42 systematic reviews were included. Most of the outcomes explored (202/211) were related to cancer. We found that 75/211 had an excellent accura

SUBMITTER: Veronese N 

PROVIDER: S-EPMC11786759 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature