Biochemical Hypogonadism in Aging Testicular Cancer Survivors: A Clinical Challenge.

ABSTRACT:

Background and objective

Few longitudinal studies have described the prevalence and development of biochemical hypogonadism in aging testicular cancer survivors (TCSs) in comparison to men from the general population (control subjects).

Methods

Serum total and free testosterone (T_total, T_free) were measured in 593 TCSs median11 and 27 years after TC diagnosis (Survey-First; Survey-Last). Post-treatment adverse health outcomes (AHOs) were recorded. The results were compared to those in 578 control subjects. Treatment was stratified as surgery alone, radiotherapy alone, or platinum-based chemotherapy. Biochemical hypogonadism was defined as T_total <8 nmol/l, or as T_total <12 nmol/l and T_free <225 pmol/l. We used multivaria

SUBMITTER: Fossa SD 

PROVIDER: S-EPMC11786855 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature