Effect of Daily Fiber Intake Among Cirrhotic Patients With and Without Portosystemic Shunts.

ABSTRACT:

Background

A diet rich in fiber, especially soluble fiber, causes cholestatic liver damage and fibrosis in animal models with intestinal dysbiosis, high serum bile acid concentrations, and congenital portosystemic shunts (PSs), but no data on patients with cirrhosis (CIRs) are available.

Objectives

To investigate whether dietary fiber consumption was associated with clinical outcomes of CIRs and whether their effect differed according to the presence of PSs.

Methods

Daily soluble and insoluble fiber intake was extrapolated from 3-d food diaries in 25 patients with chronic hepatitis (CH) and 80 CIRs outpatient liver transplant candidates abstinent from alcohol and nonviremic for ≥6 mo. In CIRs, the presence of PSs was verified by computed tomography, and the model for

SUBMITTER: Parisse S 

PROVIDER: S-EPMC11787017 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature