Interventional factors influencing natural killer cell immunity in colorectal cancer: a systematic review.

ABSTRACT:

Background and aim

Colorectal cancer (CRC) is the third most common cancer globally. Despite advances in curative CRC surgery, metastatic disease remains a significant problem. Emerging evidence suggests that several commonly used perioperative interventions may influence cancer immunity through natural killer (NK) cell function or numbers. This systematic review aimed to identify the effects of standard perioperative interventions on NK cells in CRC patients.

Methods

A systematic search of four databases, MEDLINE, EMBASE, Cochrane Library and Scopus was performed up to 30th July 2024 using keywords associated with colorectal cancer, NK cells and perioperative medications. PRISMA guidelines were followed. Critical appraisal was undertaken using the Joanna Briggs Institute Cr

SUBMITTER: Soh WS 

PROVIDER: S-EPMC11787105 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature