CD155 promotes the progression of colorectal cancer by restraining CD8⁺ T cells via the PI3K/AKT/NF-κB pathway.

ABSTRACT:

Background

CD155 is a crucial factor in the regulation of T cell function and contributes to immune escape. CD155 upregulation has been found in several types of cancer. However, the mechanism by which CD155 regulates CD8⁺ T cell function in colorectal cancer remains unclear. Here we investigated the role and mechanism of CD155 in the regulation of CD8⁺ T cell function.

Methods

We studied the expression of CD155 in colorectal cancer tissues through western blot, immunohistochemistry, and the TCGA database. We verified the effects of CD155 on the functions of colorectal cancer cells and CD8⁺ T cells through in vitro experiments. We demonstrated that CD155 affects CD8⁺ T cell migration and thus promotes tumor growth in a mouse subcut

SUBMITTER: Liang R 

PROVIDER: S-EPMC11787123 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature